精神发育迟滞相关蛋白Rab GDI α抗体
规格：1尘驳/1尘濒
英文名： GDI1
别名： 1A; FLJ41411; GDI-1; gdi1; GDIA_HUMAN; GDIL; GDP dissociation inhibitor 1; Guanosine diphosphate dissociation inhibitor 1; Mental retardation X-linked 41; Mental retardation X-linked 48; MRX41; MRX48;
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GDI1
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit, Zebrafish, Sheep, Chimpanzee
细胞定位：细胞浆
精神发育迟滞相关蛋白Rab GDI α抗体产物介绍：background: Rab proteins, a family of Ras-related small GTP-binding proteins, play a key role in regulating intracellular vesicle trafficking (1?). Rab GDP dissociation inhibitor (Rab GDI or GDI2) forms a soluble complex with Rab proteins and thereby prevents the exchange of GDP for GTP (1?). In mammals, there exist two major isoforms, Rab GDI alpha (also known as XAP-4) and Rab GDI beta (1,4). While the mammalian Rab GDI beta-genes are ubiquitously expressed, the Rab GDI ?genes are predominantly brain-specific (1). Since it is expressed predominantly in neural and sensory tissues, Rab GDI a may serve a specific function in neural signal transmission (5). The gene sequences for the Rab GDI proteins are extremely conserved in evolution, with substantial homology preserved across three 精神发育迟滞相关蛋白Rab GDI α抗体eukaryotic kingdoms (5). Function: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Subunit: Interacts with RHOH. Interacts with RAB10; negatively regulates RAB10 association with membranes and activation. Subcellular Location: Cytoplasm. Tissue Specificity: Brain; predominant in neural and sensory tissues. DISEASE: Defects in GDI1 are the cause of mental retardation X-linked type 41 (MRX41) [MIM:300104]. Mental retardation 精神发育迟滞相关蛋白Rab GDI α抗体is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Defects in GDI1 are the cause of mental retardation X-linked type 48 (MRX48) [MIM:300104]; also known as MRX3. Similarity: Belongs to the Rab GDI family. Gene ID: 2664 Database links: Entrez Gene: 2664 Human Entrez Gene: 14567 Mouse Entrez Gene: 25183 Rat Omim: 300104 Human SwissProt: P31150 Human SwissProt: P50396 Mouse SwissProt: P50398 Rat Unigene: 74576 Human Unigene: 205830 Mouse Unigene: 4000 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
精神发育迟滞相关蛋白Rab GDI α抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 信号转导 转运蛋白
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid