**内膜抗体
规格：1尘驳/1尘濒
英文名： SFRP4
别名： sFRP-4; Secreted frizzled-related protein 4; Frizzled protein, human endometrium; FrpHE; SFRP4; SFRP4_MOUSE; SFRP4_HUMAN; FRPHE.
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human sFRP-4 C
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞浆 分泌型蛋白
**内膜抗体产物介绍：background: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. [SUBCELLULAR LOCATION] Secreted. Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Belongs to the secreted frizzled-related protein (sFRP)**内膜抗体 family. Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity). Subcellular Location: Secreted. Tissue Specificity: Expressed the ovary. Localized to granulosa cells of periovulatory follicles and corpora lutea. Weakly expressed in tissues including kidney, brain and lung. Similarity: Belongs to the secreted **内膜抗体frizzled-related protein (sFRP) family. Contains 1 FZ (frizzled) domain. Contains 1 NTR domain. Gene ID: 6424 Database links: Entrez Gene: 6424 Human Entrez Gene: 20379 Mouse Entrez Gene: 89803 Rat Omim: 606570 Human SwissProt: Q6FHJ7 Human SwissProt: Q9Z1N6 Mouse SwissProt: Q9JLS4 Rat Unigene: 658169 Human Unigene: 42095 Mouse Unigene: 10788 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 抗**内膜抗体属于自身抗体，在正常育龄妇女中也可以检测到，但在不孕症人群中，特别是患有**内膜异位症的妇女中更多见。 正常机体具有自身**调节功能，产生极弱的自身抗体，帮助**体内衰老变性的自身成分，但由于某种原因导致**系统对自身组织产生过度**应答，则会发生过强的一系列**反应，致使所侵及的组织**活性细胞增多，**复合物沉积，而导致功能改变。当这种抗**内膜抗体由于反复刺激而大量产生达到一定的含量时，可与自身的**内膜组织发生抗原抗体结合反应，并激活**系统引起损伤性效应，造成**内膜组织细胞生化代谢及生理功能的损害，干扰和妨碍精卵结合，受精卵的着床和胚囊的发育而导致不孕或流产。
**内膜抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid