高尔基体卷曲螺旋蛋白2抗体
规格：1尘驳/1尘濒
英文名： GCC2
别名： 185 kDa Golgi coiled-coil protein; CLL-associated antigen KW-11; CTCL tumor antigen se1-1; GCC protein, 185 kD; GCC185; GCC2; GCC2_HUMAN; Golgi coiled coil protein GCC185; GRIP and coiled coil domain
分子量： 196kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GCC2
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
高尔基体卷曲螺旋蛋白2抗体产物介绍：background: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of 高尔基体卷曲螺旋蛋白2抗体CLASP1 and CLASP2. Function: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. 高尔基体卷曲螺旋蛋白2抗体Subunit: Homodimer. Interacts (via GRIP domain) with RAB6A (preferentially in its GTP-bound form). May interact (RAB6A-dependent) with ARL1; according to PubMed:19703403, RAB6A and ARL1 are not involved in GCC2 Golgi localization as proposed by PubMed:18243103. Interacts (probably via GRIP domain) with RAB9A (preferentially in its GTP-bound form). Interacts with CLASP1 and CLASP2; recruits both proteins to membranes of the TGN. Interacts with STX16. [INTERACTION] Self; NbExp=2; IntAct=EBI-1645335, EBI-1645335; P20340:RAB6A; NbExp=4; IntAct=EBI-1645335, EBI-1052826. Subcellular Location: Cytoplasm. Golgi apparatus; trans-Golgi network membrane. Tissue Specificity: Ubiquitous. Similarity: Contains 1 GRIP domain. Gene ID: 9648 Database links: Entrez Gene: 9648 Human Entrez Gene: 70297 Mouse Omim: 612711 Human SwissProt: Q8IWJ2 Human SwissProt: Q8CHG3 Mouse Unigene: 436505 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
高尔基体卷曲螺旋蛋白2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid