搁补产5激活蛋白6抗体
规格：1尘驳/1尘濒
英文名： GAPex5
别名： GAPEX 5; GAPVD1; GTPase activating protein and VPS9 domains 1; KIAA1521; Rab5 activating protein 6; RAP6; GAPD1_HUMAN.
分子量： 145kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GAPex5/G
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
搁补产5激活蛋白6抗体产物介绍：background: GAPVD1 is a 1478 amino acid peripheral membrane protein that acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF). GAPVD1 participates in many processes such as insulin receptor internalization, Glut4 trafficking and endocytosis. In addition, depletion of GAPVD1 leads to delayed EGFR degradation by mediating receptor ubiquination through its RGD domain, suggesting that it may be an important mediator of carcinogenesis resulting from Ras protein mutations. There are six isoforms of GAPVD1 that are produced as a result of alternative splicing events. Function: GAPex 5 plays a role in several processes such 搁补产5激活蛋白6抗体as endocytosis, insulin receptor internalisation and LC2A4/GLUT4 trafficking. It acts as both a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF). GAPex 5 is a GEF for the small G protein Rab31, promoting the exchange of GDP bound to Rab31 for GTP and thus regulating LC2A4/GLUT4 trafficking. In the absence of insulin, GAPex 5 maintains Rab31 in an active (GTP-bound) state, thereby promoting a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, keeping LC2A4/GLUT4 inside the cells. Following insulin stimulation, GAPex 5 is translocated to the plasma membrane, enabling the release of LC2A4/GLUT4 from the intracellular storage vesicles. GAPex 5 is also involved 搁补产5激活蛋白6抗体in EGFR trafficking and degradation, and also has GEF activity for Rab5 and GAP activity for Ras. Subunit: Interacts with TRIP10/CIP4 (By similarity). Interacts with RAB5A. Subcellular Location: Cell Membrane (peripheral membrane protein) and Cytoplasmic. Similarity: Belongs to the GAPVD1 family. Contains 1 Ras-GAP domain. Contains 1 VPS9 domain. Database links: Entrez Gene: 26130 Human Omim: 611714 Human SwissProt: Q14C86 Human Unigene: 495134 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
搁补产5激活蛋白6抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 G蛋白偶联受体 新陈代谢 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid