多肽狈-乙酰氨基半乳糖转移酶13抗体
规格：1尘驳/1尘濒
英文名： GALNT13
别名： GalNAc-T13; GalNAc T13; GalNAc transferase 13; N acetylgalactosaminyltransferase 13; Polypeptide GalNAc transferase 13; pp GaNTase 13; Protein UDP acetylgalactosaminyltransferase 13; UDP GalNAc:polype
分子量： 64kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GALNT13/
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
多肽狈-乙酰氨基半乳糖转移酶13抗体产物介绍：background: The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosamine) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T13 (Polypeptide N-acetylgalactosaminyltransferase 13), also known as UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13, is a 556 amino acid protein that displays much stronger enzymatic activity than GalNAc-1 towards GalNAc transfer to mucin peptides such as Muc5a and Muc7. The N-terminal domain is involved in substrate binding and manganese coordination, while the C-terminal domain is involved in UDP-Gal binding 多肽狈-乙酰氨基半乳糖转移酶13抗体and catalytic reaction. With specific expression in the central nervous system, GalNAc-T13 may be responsible for the synthesis of Tn antigen in neuronal cells, which is a universal carcinoma marker on malignant cells. Function: GALNT13 is a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAcT; EC 2.4.1.41) family, which initiate O-linked glycosylation of mucins by the initial transfer of N-acetylgalactosamine (GalNAc) with an alpha-linkage to a serine or threonine residue. It is specifically expressed in neuronal cells; expressed in fetal brain, whole brain, cerebral cortex and cerebellum; not expressed in other tissues tested. There are two named isoforms. Subcellular Location: Golgi apparatus membrane; Single pass type II membrane protein. Tissue Specificity: Specifically expressed in 多肽狈-乙酰氨基半乳糖转移酶13抗体neuronal cells. Expressed in fetal brain, whole brain, cerebral cortex and cerebellum. Not expressed in other tissues tested. Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Contains 1 ricin B-type lectin domain. Database links: Entrez Gene: 114805 Human Entrez Gene: 271786 Mouse Entrez Gene: 311039 Rat Entrez Gene: 532545 Cow Omim: 608369 Human SwissProt: Q8IUC8 Human SwissProt: Q8CF93 Mouse SwissProt: Q6UE39 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
多肽狈-乙酰氨基半乳糖转移酶13抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid