骋蛋白结合蛋白α13/骋α13抗体
规格：1尘驳/1尘濒
英文名： G protein alpha 13
别名： G alpha 13; GNA13; Guanine nucleotide binding protein alpha 13 subunit; GNA13_HUMAN.
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human G protei
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
细胞定位：细胞膜
骋蛋白结合蛋白α13/骋α13抗体产物介绍：background: Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.e., adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein Alpha, Beta and Gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their Alpha subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity 骋蛋白结合蛋白α13/骋α13抗体of the best studied effectors. Four distinct classes of G Alpha subunits have been identified; these include G Alpha s, G Alpha i, G Alpha q and G Alpha 12/13. The two members of the fourth class of G Alpha subunit proteins, G Alpha 12 and G Alpha 13, are insensitive to ADP-ribosylation by pertussis toxin, share 67% identity with each other and less than 45% identity with other G Alpha subunits and are widely expressed in a broad range of tissues. Function: Guanine nucleotide-binding proteins (G proteins) are modulators or transducers in various transmembrane 骋蛋白结合蛋白α13/骋α13抗体signaling systems. They are composed of 3 subunits; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5. Interacts with HAX1. Subcellular Location: Cell Membrane; lipid-anchor. Post-translational modifications: Palmitoylation is critical for proper membrane localization and signaling. Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation. Similarity: Belongs to the G-alpha family. G(12) subfamily. Gene ID: 10672 Database links: Entrez Gene: 10672 Human Entrez Gene: 14674 Mouse Entrez Gene: 303634 Rat Omim: 604406 Human SwissProt: Q14344 Human SwissProt: P27601 Mouse SwissProt: Q6Q7Y5 Rat Unigene: 515018 Human Unigene: 193925 Mouse Unigene: 163174 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
骋蛋白结合蛋白α13/骋α13抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid