丝裂原活化蛋白激酶4抗体
规格：1尘驳/1尘濒
英文名： MAPK4
别名： Mitogen-activated protein kinase 4; Extracellular signal-regulated kinase 4; ERK-4; MAP kinase isoform p63; p63-MAPK; MNK2; ERK-4; ERK3; Erk3 related; ERK4; Extracellular signal regulated kinase 4; MA
分子量： 66kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAPK4
交叉反应：Human, Mouse, Rat,
细胞定位：
丝裂原活化蛋白激酶4抗体产物介绍：background: Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets. [provided by RefSeq, Jul 2008] Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and丝裂原活化蛋白激酶4抗体 activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). Subunit: Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5. Subcellular Location: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. Tissue Specificity: High expression in heart and brain. Post-translational modifications: Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.丝裂原活化蛋白激酶4抗体 Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain. Gene ID: 5596 Database links: Entrez Gene: 5596 Human Entrez Gene: 225724 Mouse Entrez Gene: 54268 Rat Omim: 176949 Human SwissProt: P31152 Human SwissProt: Q6P5G0 Mouse SwissProt: Q63454 Rat Unigene: 433728 Human Unigene: 254517 Mouse Unigene: 146899 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. MAP kinase 4（MAPK4）也是MAPK家族成员，具有丝/苏氨酸激酶活性。参与细胞生长、增殖、分化、死亡及细胞间的功能同步等多种生理过程,能够被诸如细胞因子、生长因子、神经递质、**、细胞应急以及细胞粘附等各种刺激因素激活为信号传导途中重要的蛋白激酶，MAPK家族成员之间有很高的同源性。
丝裂原活化蛋白激酶4抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid