轴索过度生长抑制因子A+B抗体 Nogo-B/A
规格：1尘驳/1尘濒
英文名： Nogo A+B
别名： RTN4; RTN4-B1; Nbla10545; RTN-X; reticulon-4A; Nogo-C; NSP; RTN-x; ASY; foocen; NSP-CL; NOGOC; RTN4-A; Reticulon-4; Nbla00271; KIAA0886; NOGOA; Reticulon-5; Foocen; NI220/250; RTN4-C; RTN4-B2; SP1507;
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse Nogo-B/A
交叉反应：Human, Mouse, Rat, Dog, Sheep,
细胞定位：细胞浆 细胞膜
轴索过度生长抑制因子A+B抗体 Nogo-B/A产物介绍：background: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. Function: NOGO is a potent neurite outgrowth inhibitor which may also help block the regeneration of轴索过度生长抑制因子A+B抗体 Nogo-B/A the central nervous system in higher vertebrates. Adult mammalian axon regeneration is generally successful in the peripheral nervous system but poor in the central nervous system. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin, the insulating axon sheath. These molecules include NI35, myelin-associated glycoprotein (159460), and Nogo. Several isoforms (A-E) of NOGO exist. Subcellular Location: Endoplasmic reticulum; endoplasmic reticulum membrane;轴索过度生长抑制因子A+B抗体 Nogo-B/A multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains. Gene ID: 57142 Database links: Entrez Gene: 57142 Human Entrez Gene: 68585 Mouse Entrez Gene: 83765 Rat Omim: 604475 Human SwissProt: Q9NQC3 Human SwissProt: Q99P72 Mouse SwissProt: Q9JK11 Rat Unigene: 704007 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神经生物学相关蛋白（Neurobiology） Nogo-B蛋白是一组参与组织损伤后再生的跨膜功能蛋白，其中Nogo-B位于多种组织器官中而发挥不同的功能。目前研究发现，Nogo-B与肿瘤抑制、凋亡、神经系统再生抑制、血管内膜损伤修复等多种病理生理过程有不同程度的关系.
轴索过度生长抑制因子A+B抗体 Nogo-B/A产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid