慢性粒细胞白血病33抗体
规格：1尘驳/1尘濒
英文名： FARSLA/CML33
别名： CML 33; CML33; FARS; FARSA; FARSL; FRSA; PheHA; Phenylalanine tRNA ligase 1 alpha cytoplasmic; Phenylalanine tRNA ligase alpha chain; Phenylalanine tRNA synthetase alpha subunit; Phenylalanine tRNA sy
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FARSLA/C
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆
慢性粒细胞白血病33抗体产物介绍：background: Aminoacyl-tRNA synthetases consist of a family of enzymes that catalyze the specific aminoacylation of tRNA by their cognate amino acid in the initial step of ribosome-dependent protein biosynthesis. FARSLA, also known as FRSA, CML33, FARSL or PheHA (phenylalanyl-tRNA synthetase, alpha subunit), is a member of the class-II aminoacyl-tRNA synthetase family and is highly expressed in proliferating cells of bone marrow. FARSLA is a cytoplasmic phenylalanine-tRNA synthetase that functions as a heterodimer consisting of a catalytic alpha-subunit and a regulatory beta-subunit. The alpha-subunit is responsible for forming the amino acid binding pocket, mediating the慢性粒细胞白血病33抗体 ATP/aminoacyl adenylate binding, and interacts with the acceptor stem of the tRNA. FARSLA functions in a cell cycle-dependent and differentiation-dependent manner. Function: FARSLA (Phenylalanyl-tRNA synthetase alpha chain) is an aminoacyl-tRNA synthetase. These are a class of enzymes that charge tRNAs with their cognate amino acids. Cytoplasmic phenylalanine-tRNA synthetase is a heterodimer consisting of a catalytic alpha subunit, FARSLA, and a regulatory beta subunit, FARSLB. This protein has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase family shown to exhibit this type of 慢性粒细胞白血病33抗体regulated expression. Subcellular Location: Cytoplasmic. Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. Gene ID: 2193 Database links: Entrez Gene: 2193 Human Entrez Gene: 66590 Mouse Entrez Gene: 288917 Rat Omim: 602918 Human SwissProt: Q9Y285 Human SwissProt: Q8C0C7 Mouse SwissProt: Q505J8 Rat Unigene: 23111 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
慢性粒细胞白血病33抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid