齿滨础笔相关因子1凋亡抑制蛋白抗体
规格：1尘驳/1尘濒
英文名： FBXO39
别名： XIAP-associated factor 1; BIRC 4 binding protein; BIRC4-binding protein; XAF1; XAF1_MOUSE; XIAPAF1; BIRC 4 binding protein; BIRC4 binding protein; BIRC4BP; HSXIAPAF 1; HSXIAPAF1; XAF 1; XIAP associate
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse XAF1
交叉反应：Mouse, Rat,
细胞定位：
齿滨础笔相关因子1凋亡抑制蛋白抗体产物介绍：background: XAF1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF1 results in the neutralization of XIAP's ability to inhibit cell death. XAF1 is normally expressed in all and fetal tissues but is present at very low levels in a variety of cancer cell lines. In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines. Function: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in齿滨础笔相关因子1凋亡抑制蛋白抗体 apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The齿滨础笔相关因子1凋亡抑制蛋白抗体 BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity). Subunit: Interacts with BIRC1, BIRC2, BIRC3, BIRC4, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation (By similarity). Subcellular Location: Cytoplasm (By similarity). Nucleus (By similarity). Mitochondrion (By similarity). Similarity: Contains 1 TRAF-type zinc finger. Gene ID: 628100 Database links: Entrez Gene: 628100 Mouse Entrez Gene: 162517 Human Omim: 609106 Human SwissProt: Q8N4B4 Human SwissProt: Q5NBU5 Mouse Unigene: 368364 Human Unigene: 390365 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. XAF1是一个新近发现的通过与XIAP直接结合拮抗其抗凋亡作用的蛋白因子。XAF1是一个新的肿瘤抑制基因，XAF1在多种肿瘤细胞和组织中存在低表达或表达缺失。其过度表达可诱导凋亡，抑制肿瘤生长。
齿滨础笔相关因子1凋亡抑制蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid