贰惭厂驰蛋白抗体
规格：1尘驳/1尘濒
英文名： EMSY
别名： C11orf30; Chromosome 11 open reading frame 30; EMSY protein; FLJ90741; GL002; Protein EMSY; EMSY_HUMAN.
分子量： 141kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EMSY
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
贰惭厂驰蛋白抗体产物介绍：background: EMSY binds BRCA2 within a region (exon 3) deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2 exon 3, associates with chromatin regulators HP1 and BS69, and localizes to sites of repair following DNA damage. Its levels are amplified in breast and ovarian cancer. Function: Regulator which is able to repress transcription, possibly 贰惭厂驰蛋白抗体via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Subunit: Homodimer. Interacts with the transactivation domain of BRCA2. Interacts with the chromoshadow domain of CBX1 and with ZMYND11. Does not interact with CBX3 or CBX5. Subcellular Location: Nuclear. 贰惭厂驰蛋白抗体Localizes to DNA damage markers in irradiated cells; suggesting that it participates in the DNA repair process. Similarity: Contains 1 ENT (EMSY N-terminal) domain. Database links: UniProtKB/Swiss-Prot: Q7Z589.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
贰惭厂驰蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid