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延伸因子结合蛋白贰贵罢鲍顿2抗体

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产物名称: 延伸因子结合蛋白贰贵罢鲍顿2抗体
产物型号: EFTUD2
产物展商: 单克隆抗体/多克隆抗体
产物文档: 无相关文档

简单介绍

延伸因子结合蛋白贰贵罢鲍顿2抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。延伸因子结合蛋白贰贵罢鲍顿2抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产物质量,质量稳定,实验效果明显。


延伸因子结合蛋白贰贵罢鲍顿2抗体  的详细介绍

延伸因子结合蛋白贰贵罢鲍顿2抗体

规格:1尘驳/1尘濒

英文名: EFTUD2

别名: 116 kDa; 116 kDa U5 small nuclear ribonucleoprotein component; EFTUD2; Elongation factor Tu GTP binding domain containing 2; Elongation factor Tu GTP-binding domain-containing protein 2; hSNU114; MFDM

分子量: 109kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:笔辞濒测肠濒辞苍补濒

亚型:滨驳骋

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human EFTUD2

交叉反应:Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,

细胞定位:细胞核

延伸因子结合蛋白贰贵罢鲍顿2抗体产物介绍:background: Spliceosomes are multi-protein complexes that are composed of snRNPs (small nuclear ribonucleoproteins) and a variety of associated protein factors, all of which work in concert to regulate the splicing of pre-mRNA. Snrp116, also known as EFTUD2 (elongation factor Tu GTP binding domain containing 2) or Snu114, is a 972 amino acid protein that localizes to the nucleus and belongs to the GTP-binding elongation factor family. Existing as a component of the multi-protein U5 snRNP spliceosome complex, Snrp116 plays an important role in pre-mRNA splicing, as well as in the recycling of spliceosomal snRNPs. The gene encoding Snrp116 maps to human 延伸因子结合蛋白贰贵罢鲍顿2抗体chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Function: Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP. Subunit: Identified in the spliceosome C complex. Interacts with ERBB4 and PRPF8. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR延伸因子结合蛋白贰贵罢鲍顿2抗体. DISEASE: Defects in EFTUD2 are the cause of mandibulofacial dysostosis with microcephaly (MFDM) [MIM:610536]. A rare syndrome characterized by progressive microcephaly, midface and malar hypoplasia, micrognathia, microtia, dysplastic ears, preauricular skin tags, significant developmental delay, and speech delay. Many patients have major sequelae, including choanal atresia that results in respiratory difficulties, conductive hearing loss, and cleft palate. Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily. Database links: UniProtKB/Swiss-Prot: Q15029.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

延伸因子结合蛋白贰贵罢鲍顿2抗体产物应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  表观遗传学  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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