酶动力蛋白1抗体
规格：1尘驳/1尘濒
英文名： Dynamin 1
别名： B dynamin; D100; DNM 1; DNM; DNM1; DYN1_HUMAN; Dynamin; Dynamin-1; Dynamin1.
分子量： 97kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Dynamin
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Sheep,
细胞定位：细胞浆
酶动力蛋白1抗体产物介绍：background: Dynamin I is a GTPase enzyme required for the retrieval of synaptic vesicles after exocytosis and functions in endocytosis by stimulating assembly of invaginating synaptic vesicles (1). Dynamin I is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C (PKC) (2–5). The phosphorylation site in PKC-phosphorylated Dynamin I is a single site at Serine 795, which is located near a binding site for the SH3 domain of p85, the regulatory subunit of phosphatidylinositol 3-kinase (2–5). Dephosphorylation is required for synaptic vesicle retrieval, suggesting that phosphorylation affects the subcellular localization of Dynamin I (5).酶动力蛋白1抗体 Mouse, rat and human Dynamin I are phosphorylated on serine residues, including Ser 778, by Cdk5, regulating PACSIN1 recruitment and enabling synaptic vesicle endocytosis. Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. Subunit: Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain). Subcellular Location: Cytoplasm; Cytoplasm; cytoskeleton; Microtubule-associated. Similarity: Belongs to the dynamin family. 酶动力蛋白1抗体Contains 1 GED domain. Contains 1 PH domain. Database links: Entrez Gene: 1759 Human Entrez Gene: 13429 Mouse Entrez Gene: 140694 Rat Omim: 602377 Human SwissProt: Q05193 Human SwissProt: P39053 Mouse SwissProt: P21575 Rat Unigene: 522413 Human Unigene: 44736 Mouse Unigene: 10354 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
酶动力蛋白1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 转运蛋白 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid