顿狈础甲基转移酶2抗体
规格：1尘驳/1尘濒
英文名： Dnmt2
别名： dDNMT; DmMT 2; DmMT2; DNA (cytosine 5 ) methyltransferase 2; DNA (cytosine 5) methyltransferase like protein 2; DNA (cytosine-5)-methyltransferase-like protein 2; DNA 5 cytosine methyltransferase; DNA
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Dnmt2
交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,
细胞定位：细胞核
顿狈础甲基转移酶2抗体产物介绍：background: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian 顿狈础甲基转移酶2抗体Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two 顿狈础甲基转移酶2抗体distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA. Function: Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes. Similarity: Belongs to the C5-methyltransferase family. Database links: UniProtKB/Swiss-Prot: O14717.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
顿狈础甲基转移酶2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid