奥苍迟通路抑制因子2抗体
规格：1尘驳/1尘濒
英文名： DKK2
别名： Dickkopf 2; Dickkopf gene 2; Dickkopf homolog 2; Dickkopf related protein 2; Dickkopf-2; Dickkopf-related protein 2; Dickkopf2; DKK 2; Dkk-2; Dkk2; DKK2_HUMAN; hDkk 2; hDkk-2; hDkk2.
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DKK2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep,
细胞定位：分泌型蛋白
奥苍迟通路抑制因子2抗体产物介绍：background: The Wnt genes are a group of well conserved, cysteine-rich secreted glycoproteins that are required for numerous develop-mental processes including embryogenesis, asymmetric cell division and central nervous system (CNS) patternins. Wnt association with the seven membrane spanning receptor Frizzled, activates Dishevelled, which downregulates glycogen synthase kinase (GSK) through serine phosphorylation, causing the accumulation of b-Catenin and subsequent regulation of developmentally significant Wnt target genes. The Dickkopf family of secreted inhibitors of Wnt signaling ensures proper morphological development by antagonizing different stages of奥苍迟通路抑制因子2抗体 the Wnt cascade. Dkk-2 (Dickkopf-2) is a 259-amino acid secreted protein that is composed of an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a 50-55-amino acid linker region. Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the , Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.奥苍迟通路抑制因子2抗体 Subunit: Interacts with LRP5 and LRP6 (By similarity). Subcellular Location: Secreted. Tissue Specificity: Expressed in heart, brain, skeletal muscle and lung. Post-translational modifications: May be proteolytically processed by a furin-like protease. Similarity: Belongs to the dickkopf family. Database links: Entrez Gene: 27123 Human Entrez Gene: 56811 Mouse Omim: 605415 Human SwissProt: Q9UBU2 Human SwissProt: Q9QYZ8 Mouse SwissProt: Q9DDA4 Xenopus laevis Unigene: 211869 Human Unigene: 103593 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
奥苍迟通路抑制因子2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 干细胞 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid