清道夫脱帽酶/热休克蛋白1抗体
规格：1尘驳/1尘濒
英文名： DCPS
别名： 1700001E16Rik; AA408441; DCPS; DCPS_HUMAN; DCS 1; DCS-1; DCS1; Decapping enzyme scavenger; heat shock-like protein 1; Hint 5; Hint related 7meGMP directed hydrolase; HINT-5; Hint-related 7meGMP-direct
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DCPS
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆
清道夫脱帽酶/热休克蛋白1抗体产物介绍：background: Eukaryotic cells primarily utilize exoribonucleases and decapping enzymes to degrade their mRNA. DcpS is a scavenger pyrophosphatase that hydrolyzes the residual cap structure following 3' to 5' decay of an mRNA. Following mRNA degradation DcpS releases N-7 methyl guanosine monophosphate and 5'-diphosphate terminated cap or mRNA products. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. HIT proteins are homodimeric and contain two conserved 清道夫脱帽酶/热休克蛋白1抗体100-amino-acid HIT fold domains with independent active sites that are each sufficient to bind and hydrolyze cognate substrates. Function: Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated 清道夫脱帽酶/热休克蛋白1抗体mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides. Subunit: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Detected in liver, brain, kidney, testis and prostate. Similarity: Belongs to the HIT family. Database links: UniProtKB/Swiss-Prot: Q96C86.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
清道夫脱帽酶/热休克蛋白1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid