细胞色素P450 19抗体
规格：1尘驳/1尘濒
英文名： CYP19
别名： ARO 1; ARO; ARO1; ARO1; Aromatase; CP19A_HUMAN; CPV; CPV1; CYAR; CYP19; CYP19A1; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Cytochrome P450 family 19 subfamily A polypeptide 1; Cytochrome P45
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CYP19
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
细胞色素P450 19抗体产物介绍：background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. Belongs to the cytochrome P450 family. Function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Subcellular Location: 细胞色素P450 19抗体Membrane; Peripheral membrane protein. Tissue Specificity: Brain, placenta and gonads. DISEASE: Defects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:139300]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity. Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:613546]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism,细胞色素P450 19抗体 which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries. Similarity: Belongs to the cytochrome P450 family. Gene ID: 1588 Database links: Entrez Gene: 1588 Human Entrez Gene: 13075 Mouse Entrez Gene: 25147 Rat Omim: 107910 Human SwissProt: P11511 Human SwissProt: P28649 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 芳香化酶基因(CYP19)编码的芳香化酶是催化雄**向雌**转化的关键酶,CYP19的变异可使芳香化酶活性改变,导致雌**水平的改变,从而使乳腺癌易感性发生改变,也可能影响到乳腺癌的敏感性。 目前对于CYP19基因多态性与乳腺癌之间的关系仍存在争论,尚需深入研究以明确芳香化酶的基因多态性在乳腺癌发生中的作用,以及该基因多态性对芳香化酶功能的影响。
细胞色素P450 19抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid