生长抑制因子基因1抗体
规格：1尘驳/1尘濒
英文名： ING1
别名： ING1_HUMAN; Inhibitor of growth protein 1; inhibitor of growth gene 1; Growth inhibitor ING 1; Growth inhibitor ING1; Growth inhibitory protein ING 1; Growth inhibitory protein ING1; Homo sapiens grow
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human inhibito
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
生长抑制因子基因1抗体产物介绍：background: This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]. Function: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. Subcellular Location: Nucleus. Tissue Specificity: Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines生长抑制因子基因1抗体 examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines. DISEASE: Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck. Similarity: Belongs to the ING family. Contains 1 PHD-type zinc finger.生长抑制因子基因1抗体 Gene ID: 3621 Database links: Entrez Gene: 3621 Human Entrez Gene: 26356 Mouse Entrez Gene: 306626 Rat GenBank: NP_937862 Human Omim: 601566 Human SwissProt: Q9UK53 Human SwissProt: Q9QXV3 Mouse Unigene: 46700 Human Unigene: 508725 Human Unigene: 25709 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肿瘤的发生是一个多基因参与,多步骤发生的复杂过程，抑癌基因的功能失活与癌基因的激活为其主要原因之一。 ING1基因是近期发现的抑癌基因，研究发现，它的过表达可抑制细胞生长、增殖,促进细胞凋亡，它的低表达与肿瘤的发生、发展有关。ING1正常时定位于胞核，发挥其诱导凋亡和调控细胞周期的作用，当其易位于胞质时上述作用逐步减弱或消失，在肿瘤发生时，多位于胞浆。
生长抑制因子基因1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞凋亡 细胞周期蛋白 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid