生长分化因子8抗体
规格：1尘驳/1尘濒
英文名： GDF8
别名： GDF 8; GDF-8; GDF8_HUMAN; Growth differentiation factor 8; Growth/Differentiation Factor 8; MSTN; myostatin; OTTHUMP00000163498.
分子量： 12/43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GDF8 (30
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep,
细胞定位：分泌型蛋白
生长分化因子8抗体产物介绍：background: The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. Acts specifically as a negative regulator of skeletal muscle growth. [SUBUNIT] Homodimer; [TISSUE SPECIFICITY] Expressed specifically in developing and skeletal muscle. Weak expression in adipose tissue. Belongs to the TGF-beta family. Function: Acts specifically as a negative regulator of skeletal 生长分化因子8抗体muscle growth. Subunit: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3. Subcellular Location: Secreted Tissue Specificity: Predominantly expressed in muscle. At hatching, expression is strongest in the skin epithelium, and is also found in the retina and brain. From day 28, expressed in skeletal muscle. In the , highest expression is seen in the gastrointestinal tract, brain生长分化因子8抗体, muscle, heart and testis. Also expressed in the pharynx, kidney, spleen, liver, gill, eyes, skin, swim bladder and ovary. DISEASE: Defects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Similarity: Belongs to the TGF-beta family. Gene ID: 2660 Database links: Entrez Gene: 2660 Human Entrez Gene: 17700 Mouse Entrez Gene: 373964 Chicken Entrez Gene: 399534 Pig Entrez Gene: 29152 Rat Entrez Gene: 798441 Zebrafish Omim: 601788 Human SwissProt: O14793 Human SwissProt: O08689 Mouse SwissProt: O35312 Rat SwissProt: O18830 Sheep SwissProt: O42222 Zebrafish Unigene: 41565 Human Unigene: 3514 Mouse Unigene: 44460 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GDF-8又称MSTN,是转化生长因子超家族，也是近年来发现的一类重要的肌细胞生长调控因子，它通过抑制MyoD家族成员转录活性负向控制生长分化因子8抗体肌细胞的生长发育，它的表达量与肌肉重量的变化呈负相关。
产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid