生长分化因子8/肌肉抑制素抗体
规格：1尘驳/1尘濒
英文名： GDF8
别名： MSTN; growth differntiation factor 8; GDF 8; Growth differentiation factor 8; Growth/Differentiation Factor 8; myostatin; GDF8_HUMAN.
分子量： 12/43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GDF8
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：分泌型蛋白
生长分化因子8/肌肉抑制素抗体产物介绍：background: Myostatin (GDF8)is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor beta superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology. Function: Acts specifically as a negative regulator of skeletal muscle growth. Subunit: Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3. Subcellular 生长分化因子8/肌肉抑制素抗体Location: Secreted. Tissue Specificity: Predominantly expressed in muscle. At hatching, expression is strongest in the skin epithelium, and is also found in the retina and brain. From day 28, expressed in skeletal muscle. In the , highest expression is seen in the gastrointestinal tract, brain, muscle, heart and testis. Also expressed in the pharynx, kidney, spleen, liver, gill, eyes, skin, swim bladder and ovary. 生长分化因子8/肌肉抑制素抗体DISEASE: Defects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Similarity: Belongs to the TGF-beta family. Database links: UniProtKB/Swiss-Prot: O14793.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GDF-8又称MSTN,是转化生长因子超家族，也是近年来发现的一类重要的肌细胞生长调控因子，它通过抑制MyoD家族成员转录活性负向控制肌细胞的生长发育，它的表达量与肌肉重量的变化呈负相关。
生长分化因子8/肌肉抑制素抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 生长因子和** 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Goat
外观： Lyophilized or Liquid