核糖体合成蛋白叠翱笔1抗体
规格：1尘驳/1尘濒
英文名： BOP1
别名： AU020183; AW146150; Block of proliferation 1; Block of proliferation 1 protein; Bop1; Bop1 block of proliferation 1; BOP1_HUMAN; D18861; Erb1p; Kiaa0124; MGC109114; mKIAA0124; Ribosome biogenesis prot
分子量： 84kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BOP1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
细胞定位：细胞核
核糖体合成蛋白叠翱笔1抗体产物介绍：background: Predominantly localized to the nucleolus, BOP1 (Block of proliferation 1 protein) is a 746 amino acid highly conserved non-ribosomal protein that is involved in ribosome biogenesis. Truncation of the amino terminus of BOP1 leads to cell growth arrest in the G1 phase and specific inhibition of 28S and 5.8S rRNA synthesis, as well as a deficit in the cytosolic 60S ribosomal subunit. This suggests that BOP1 is involved in the formation of mature rRNAs and in the biogenesis of the 60S ribosomal subunit. BOP1 physically核糖体合成蛋白叠翱笔1抗体 interacts with pescadillo (a protein involved in cell proliferation) and enables efficient incorporation of pescadillo into the nucleolar preribosomal complexes, thereby affecting rRNA maturation and the cell cycle. The BOP1-pescadillo complex is also necessary for biogenesis of 60S ribosomal subunits. Deregulation of BOP1 may lead to colorectal tumorigenesis. Function: Component of the PeBoW complex, which is核糖体合成蛋白叠翱笔1抗体 required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Subunit: Component of the PeBoW complex, composed of BOP1, PES1and WDR12. Within the PeBoW complex BOP1 interacts directly withPES1 and WDR12. The PeBoW complex also associates with the 66Spre-ribosome. Subcellular Location: Nucleus Similarity: Belongs to the WD repeat BOP1/ERB1 family. Contains 7 WD repeats. Database links: UniProtKB/Swiss-Prot: Q14137.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核糖体合成蛋白叠翱笔1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid