奥础颁蛋白抗体
规格：1尘驳/1尘濒
英文名： WAC
别名： 1110067P07Rik; BA48B24; BA48B24.1; BM 016; FLJ31290; KIAA1844; MGC10753; OTTHUMP00000019380; OTTHUMP00000019382; PRO1741; wac; WAC_HUMAN; WW domain containing adapter protein with coiled coil; WW doma
分子量： 83kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human WAC
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞核
奥础颁蛋白抗体产物介绍：background: The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] Function奥础颁蛋白抗体: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Subcellular Location: Nucleus 奥础颁蛋白抗体speckle. Nucleus. In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes. Post-translational modifications: Phosphorylated on tyrosine residues. Similarity: Contains 1 WW domain. Database links: Entrez Gene: 51322 Human Entrez Gene: 225131 Mouse Omim: 615049 Human SwissProt: Q9BTA9 Human SwissProt: Q924H7 Mouse Unigene: 435610 Human Unigene: 204524 Mouse Unigene: 482081 Mouse Unigene: 491095 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
奥础颁蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid