线粒体丝氨酸蛋白酶抗体
规格：1尘驳/1尘濒
英文名： HTRA2
别名： HtrA2 / Omi; HTRA2; OMI; High temperature requirement protein a2; HTRA 2; HtrA like serine protease; HtrA serine peptidase 2; Omi stress regulated endoprotease; PARK 13; PARK13; Protease serine 25; PR
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HtrA2
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit,
细胞定位：细胞浆 细胞膜 线粒体
线粒体丝氨酸蛋白酶抗体产物介绍：background: This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq, Jul 2008] Function: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves 线粒体丝氨酸蛋白酶抗体THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. Subunit: Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions. The mature protein, but not the precursor, binds to BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with BIRC6/bruce. Subcellular Location: Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein (Potential). Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID. Tissue Specificity: Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid. DISEASE: Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) [MIM:610297]. 线粒体丝氨酸蛋白酶抗体A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. Similarity: Belongs to the peptidase S1B family. Contains 1 PDZ (DHR) domain. Gene ID: 27429 Database links: Entrez Gene: 27429 Human Entrez Gene: 64704 Mouse Entrez Gene: 297376 Rat Omim: 606441 Human SwissProt: O43464 Human SwissProt: Q9JIY5 Mouse Unigene: 469045 Human Unigene: 21880 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. HtrA2/Omi是一种寡聚丝氨酸蛋白酶,存在于大部分的正常组织器官中,当细胞受到凋亡刺激时,HtrA2/Omi可由线粒体膜间隙(mitochondrial intermembrane space)释放进入细胞质中,导致出现大量的细胞凋亡性死亡，Omi/HtrA2 为促凋亡因子。
线粒体丝氨酸蛋白酶抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 新陈代谢 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid