脯氨酸二肽酶抗体
规格：1尘驳/1尘濒
英文名： PEPD
别名： Aminoacyl L proline hydrolase; Imidodipeptidase; MGC10905; MGC95081; Pep 4; Pep4; pepD; PEPD_HUMAN; Peptidase 4; Peptidase D; Prolidase; Proline dipeptidase; X pro dipeptidase; X-Pro dipeptidase; Xaa-
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PEPD
交叉反应：Human, Mouse, Rat, Chicken, Rabbit, Zebrafish,
细胞定位：
脯氨酸二肽酶抗体产物介绍：background: This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] Function: Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen. Subunit: Interacts with TRAF6, IRAK1, IRAK4 and MAP3K7. Interacts脯氨酸二肽酶抗体 with BCL10; this interaction is impaired by SOCS3 (By similarity). Post-translational modifications: Phosphorylated by IRAK1 and IRAK4 enhancing its E3 ligase activity. DISEASE: Defects in PEPD are a cause of prolidase deficiency (PD) [MIM:170100]. Prolidase deficiency is an autosomal recessive disorder associated with iminodipeptiduria. The clinical phenotype includes skin ulcers, mental retardation, recurrent infections, and a characteristic facies. These features, however are incompletely penetrant and highly variable in both age of onset and severity. There is a tight linkage 脯氨酸二肽酶抗体between the polymorphisms of prolidase and the myotonic dystrophy trait. Similarity: Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily. Database links: Entrez Gene: 5184 Human Entrez Gene: 18624 Mouse Entrez Gene: 292808 Rat Omim: 613230 Human SwissProt: P12955 Human SwissProt: Q11136 Mouse SwissProt: Q5I0D7 Rat Unigene: 36473 Human Unigene: 69751 Mouse Unigene: 101639 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脯氨酸二肽酶抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞骨架 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid