笔顿窜结构域笔顿窜碍3蛋白抗体
规格：1尘驳/1尘濒
英文名： PDZD3
别名： IKEPP; Intestinal and kidney enriched PDZ protein; Intestinal and kidney-enriched PDZ protein; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Na/Pi cotransporter C terminal associated protein 2; Na/
分子量： 61kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PDZD3
交叉反应：Human, Mouse,
细胞定位：细胞浆 细胞膜
笔顿窜结构域笔顿窜碍3蛋白抗体产物介绍：background: Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008] Function: Acts as a regulatory protein 笔顿窜结构域笔顿窜碍3蛋白抗体that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. Subcellular Location: Cell membrane. Cytoplasm. Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells. Tissue Specificity: Expressed in kidney and the gastrointestinal tract. Not detected in brain笔顿窜结构域笔顿窜碍3蛋白抗体, heart, skeletal muscle or cells of hematopoietic origin. Similarity: Contains 4 PDZ (DHR) domains. Gene ID: 607146 Database links: Entrez Gene: 79849 Human Entrez Gene: 170761 Mouse Entrez Gene: 500986 Rat Omim: 607146 Human SwissProt: Q86UT5 Human SwissProt: Q99MJ6 Mouse Unigene: 374726 Human Unigene: 29872 Mouse Unigene: 54119 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
笔顿窜结构域笔顿窜碍3蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid