础罢笔6痴1叠2蛋白抗体
规格：1尘驳/1尘濒
英文名： ATP6V1B2
别名： V-ATPase B2; ATP6B1B2; ATP6B2; ATP6V1 B2; ATP6V1B 2; ATP6V1B2; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B isoform 2; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B2; ATPase H+ tran
分子量： 56kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ATP6V1B2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Cynomolgus Monkey, Orangutan
细胞定位：细胞膜
础罢笔6痴1叠2蛋白抗体产物介绍：background: Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A–H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. The V-ATPase V1 B subunit exists as two isoforms. In the inner ear, the V-ATPase B1 isoform functions in proton secretion and is required to maintain proper endolymph pH and normal auditory function. The gene encoding the human V-ATPase B1 isoform maps to chromosome 2cen-q13. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural础罢笔6痴1叠2蛋白抗体 deafness. The V-ATPase B2 isoform is expressed in kidney and is the only B isoform expressed in osteoclasts. The gene encoding the human V-ATPase B2 isoform maps to chromosome 8p22-p21. Function: Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Subunit: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein). Subcellular Location: Endomembrane system. Melanosome. Endomembrane. Identified by础罢笔6痴1叠2蛋白抗体 mass spectrometry in melanosome fractions from stage I to stage IV. Similarity: Belongs to the ATPase alpha/beta chains family. Database links: Entrez Gene: 526 Human Entrez Gene: 11966 Mouse Entrez Gene: 100173673 Orangutan Entrez Gene: 117596 Rat Entrez Gene: 338082 Cow Omim: 606939 Human SwissProt: P31408 Cow SwissProt: P21281 Human SwissProt: P62814 Mouse SwissProt: Q5R5V5 Orangutan SwissProt: P62815 Rat Unigene: 295917 Human Unigene: 249096 Mouse Unigene: 8109 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
础罢笔6痴1叠2蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 信号转导 新陈代谢 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid