础罢笔6痴0顿2蛋白抗体
规格：1尘驳/1尘濒
英文名： ATP6V0D2
别名： V-ATPase D2; ATP6D2; ATPase H+ transporting lysosomal 38kDa V0 subunit D; ATPase H+ transporting lysosomal 38kDa V0 subunit D isoform 2; ATPase H+ transporting lysosomal 38kDa V0 subunit D2; FLJ38708;
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ATP6V0D2
交叉反应：Human, Mouse, Rat, Dog, Pig, Sheep,
细胞定位：细胞浆 细胞膜
础罢笔6痴0顿2蛋白抗体产物介绍：background: Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A–H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. V-ATPase D2 is a 350 amino acid protein that is expressed in kidney, lung 础罢笔6痴0顿2蛋白抗体and osteoclast. V-ATPase D2 has been implicated as a regulator of urine acidification, osteoclast fusion and bone formation. Furthermore, V-ATPase D2 has been identified as a dendritic cell marker. Function: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Subunit: V-ATPase is a 础罢笔6痴0顿2蛋白抗体heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Subcellular Location: Apical plasma membrane. Tissue Specificity: Kidney, osteoclast and lung. Similarity: Belongs to the V-ATPase V0D/AC39 subunit family. Database links: Entrez Gene: 245972 Human Entrez Gene: 242341 Mouse Entrez Gene: 297932 Rat SwissProt: Q8N8Y2 Human SwissProt: Q80SY3 Mouse SwissProt: Q5FVL0 Rat Unigene: 436360 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
础罢笔6痴0顿2蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid