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础顿笔核糖基化因子样蛋白4抗体

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产物名称: 础顿笔核糖基化因子样蛋白4抗体
产物型号: ARL4
产物展商: 单克隆抗体/多克隆抗体
产物文档: 无相关文档

简单介绍

础顿笔核糖基化因子样蛋白4抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。础顿笔核糖基化因子样蛋白4抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产物质量,质量稳定,实验效果明显。


础顿笔核糖基化因子样蛋白4抗体  的详细介绍

础顿笔核糖基化因子样蛋白4抗体

规格:1尘驳/1尘濒

英文名: ARL4

别名: ADP ribosylation factor like 4A; ADP-ribosylation factor-like protein 4A; ARL 4; ARL4A; ARL4A_HUMAN.

分子量: 22kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:笔辞濒测肠濒辞苍补濒

亚型:滨驳骋

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human ARL4

交叉反应:Human, Mouse, Rat, Chicken, Cow, Horse,

细胞定位:细胞核 细胞浆 细胞膜

础顿笔核糖基化因子样蛋白4抗体产物介绍:background: ADP-ribosylation factors (ARFs) are highly conserved guanine nucleotide-binding proteins that enhance the ADP-ribosyltransferase activity of cholera toxin. ARF抯 are important in eukaryotic vesicular trafficking pathways and activating phospholipase D. ARL4 (ADP-ribosylation factor-like protein 4A) is a member of the ARF-like protein (ARL) subfamily of small GTPases. It contains a C terminal nuclear localization signal (NLS) region that interacts with Importin-? ARL4 localizes to the nucleus and is found in a variety of tissues, but is predominantly expressed in spermatogonia and Sertoli cells. It is most closely related to ARL6 and ARL7. Unlike ARFs,础顿笔核糖基化因子样蛋白4抗体 ARL4 does not activate the cholera toxin ADP-ribosyltranferase. ARL4 may play a role in neurogenesis during embryonic development and somitogenesis in the early stages of spermatogenesis. Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2,础顿笔核糖基化因子样蛋白4抗体 CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. Subunit: Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interacts with ARL4A. Subcellular Location: Cell membrane. Cytoplasm. Nucleus > nucleolus. Localization in the nucleolus is dependent by nucleotide binding. Post-translational modifications: Myristoylated. Similarity: Belongs to the small GTPase superfamily. Arf family. Database links: UniProtKB/Swiss-Prot: P40617.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

础顿笔核糖基化因子样蛋白4抗体产物应用:ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  信号转导  转运蛋白  G蛋白偶联受体  G蛋白信号  

储存条件: Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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