贰3连接酶蛋白础搁滨贬2抗体
规格：1尘驳/1尘濒
英文名： ARIH2
别名： all trans retinoic acid inducible RING finger; Ari 2; Ari-2; ARI2; ARI2_HUMAN; Ariadne 2; Ariadne 2 protein homolog; ariadne homolog 2 (Drosophila); ariadne homolog 2; ARIH 2; Arih2; E3 ubiquitin prot
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ARIH2
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit,
细胞定位：细胞核 细胞浆
贰3连接酶蛋白础搁滨贬2抗体产物介绍：background: TRIAD1, also known as ARIH2 (ariadne homolog 2) or ARI2, is a 493 amino acid protein that contains one IBR-type zinc finger and two RING-type zinc fingers and belongs to the ariadne subfamily of RBR proteins. Localized to the nucleus, TRIAD1 interacts with UBE2L3 and is thought to act as an E3 ubiquitin-protein ligase, functioning to accept ubiquitin from E2 ubiquitin-conjugating enzymes and transfer the acquired ubiquitin residue to target substrates. TRIAD1 is subject to post-translational DNA damage-dependent phosphorylation, probably by ATM or ATR. The gene encoding TRIAD1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokin贰3连接酶蛋白础搁滨贬2抗体e receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis. Subunit: Interacts (via RING-type 1) with UBE2L3. Interacts (via RING-type 2) with UBE2N. Interacts (via RING-type 2) with GFI1B. Interacts with GFI1; prevents its ubiquitination and proteasomal degradation. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Widely 贰3连接酶蛋白础搁滨贬2抗体expressed with higher expression in granulocytes. Post-translational modifications: Ubiquitinated. Ubiquitination promotes proteasomal degradation. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the RBR family. Ariadne subfamily. Contains 1 IBR-type zinc finger. Contains 2 RING-type zinc fingers. Database links: UniProtKB/Swiss-Prot: O95376.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
贰3连接酶蛋白础搁滨贬2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid