Rho GTP酶激活蛋白15抗体
规格：1尘驳/1尘濒
英文名： ARHGAP15
别名： ArhGAP15; BM046; Rho GTPase activating protein 15; Rho type GTPase activating protein 15; RHG15_HUMAN.
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ARHGAP15
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
Rho GTP酶激活蛋白15抗体产物介绍：background: Rho GTPases, which play fundamental roles in numerous cellular processes, are initiated by external stimuli that signal though G-protein coupled receptors. ARHGEF15 (Rho guanine nucleotide exchange factor (GEF) 15), also known as ARGEF15 or Vsm-RhoGEF, is a 841 amino acid protein expressed in the vascular smooth muscle of coronary artery. ARHGEF15 functions as a specific guanine nucleotide exchange factor for RhoA and interacts with ephrin-A4 in vascular smooth muscle cells. Containing oneRho GTP酶激活蛋白15抗体 DH (DBL-homology) domain, ARHGEF15 is phosphorylated on tyrosine residues upon ephrin-A1 stimulation. The DH domain consists of a region of about 150 amino acids that induces Rho family GTPases to release GDP. This effectively activates the Rho GTPase by allowing GTP binding. ARHGEF15 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes Rho GTP酶激活蛋白15抗体over 1,200 genes. Function: ARHGAP15 is an activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Overexpression results in an increase in actin stress fibers and cell contraction. Subcellular Location: Cytoplasm. Membrane; Peripheral membrane protein Similarity: Contains 1 PH domain. Contains 1 Rho-GAP domain. Database links: UniProtKB/Swiss-Prot: Q53QZ3.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Rho GTP酶激活蛋白15抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid