腺瘤性结肠息肉病蛋白2抗体
规格：1尘驳/1尘濒
英文名： APC2
别名： Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APCL; APC2_HUMAN.
分子量： 244kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human APCL/APC
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse,
细胞定位：细胞浆 细胞膜
腺瘤性结肠息肉病蛋白2抗体产物介绍：background: The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner’s syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with 腺瘤性结肠息肉病蛋白2抗体structural components of intracellular junctions. b-catenin and g-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both b- and g-catenin. Interactions between cytoskeleton and the APC, E cadherin, b/g catenin complex are mediated by a-catenin. Function: APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor. Subunit: Interacts with PSRC1 (By similarity).腺瘤性结肠息肉病蛋白2抗体 Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2. Subcellular Location: Cell Membrane, Cytoplasmic and Golgi Apparatus Tissue Specificity: Widely expressed (at protein level). Specifically expressed in the CNS. Similarity: Belongs to the adenomatous polyposis coli (APC) family. Contains 6 ARM repeats. Gene ID: 29882 Database links: Entrez Gene: 29882 Human Entrez Gene: 99152 Mouse Entrez Gene: 296558 Rat Omim: 606946 Human SwissProt: Q9UJX6 Human SwissProt: Q8BZQ7 Mouse Unigene: 434898 Human Unigene: 533262 Human Unigene: 291624 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
腺瘤性结肠息肉病蛋白2抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 细胞粘附分子 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid