细胞质分裂付出蛋白5抗体
规格：1尘驳/1尘濒
英文名： DOCK5
别名： Dedicator of cytokinesis 5; Dedicator of cytokinesis protein 5; DKFZp451J181; DKFZp779M164; DKFZp781J211; Dock 5; DOCK5_HUMAN.
分子量： 215kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DOCK5
交叉反应：Human, Mouse, Rat, Dog, Rabbit,
细胞定位：细胞浆
细胞质分裂付出蛋白5抗体产物介绍：background: DOCK 5 is a 1,870 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins. This cytoplasmic peripheral membrane protein activates Rac 1 and Rac 2 small GTPases, while presumably acting as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. DOCK 5 contains one DHR-1 (CZH-1) domain, one DHR-2 (CZH-2) domain and one SH3 domain. The DHR-2 domain is a putative GEF activity mediator. In mice, spontaneous mutation of the gene encoding细胞质分裂付出蛋白5抗体 DOCK 5 leads to deletion of the DHR-1 domain, which functions to bind phospholipids and assists in protein-protein interactions, resulting in rupture of lens cataract (RLC). Due to siRNA knockdown studies, it is suspected that DOCK 5 may also be an important mediator of CrkII/CrkL regulation of Caco-2 migration and spreading on COL4. There are two isoforms of DOCK 5 that exist as a result of alternative细胞质分裂付出蛋白5抗体 splicing events. Function: Dock5 (Dedicator of cytokinesis 5) is a potential guanine nucleotide exchange factor (GEF). Subcellular Location: Cytoplasm Similarity: Belongs to the DOCK family. Contains 1 DHR-1 domain. Contains 1 DHR-2 domain. Contains 1 SH3 domain. Database links: UniProtKB/Swiss-Prot: Q9H7D0.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞质分裂付出蛋白5抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid