激活素受体2础抗体
规格:1尘驳/1尘濒
英文名: Activin receptor type-2A
别名: Activin Receptor Type IIA; Activin A receptor type IIA; Activin receptor type 2A; Activin receptor type IIA; Activin receptor type-2A; ACTR 2; ACTR IIA; ACTR-IIA; ACTR2; ACTR 2; ACTR-2; ACTRII; ACTRII
分子量: 56kDa
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型:笔辞濒测肠濒辞苍补濒
亚型:滨驳骋
纯化方法:affinity purified by Protein A
**原:KLH conjugated synthetic peptide derived from human ACTR2
交叉反应:Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位:细胞膜
激活素受体2础抗体产物介绍:background: Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex (1). Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B) (1-6). Both receptor types are highly expressed in brain (5). The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion (5,6). Function: On ligand binding, forms a receptor complex 激活素受体2础抗体consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Subunit: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. Gene ID: 92 Database links: Entrez Gene: 281598 Cow Entrez Gene: 92 Human Entrez Gene: 11480 Mouse Entrez Gene: 29263激活素受体2础抗体 Rat Entrez Gene: 553359 Zebrafish Omim: 102581 Human SwissProt: P27037 Human SwissProt: P27038 Mouse SwissProt: P38444 Rat Unigene: 470174 Human Unigene: 314338 Mouse Unigene: 161783 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
激活素受体2础抗体产物应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域:细胞生物 信号转导 干细胞 激酶和磷酸酶 结合蛋白 细胞表面分子 细胞骨架 新陈代谢
储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源: Rabbit
外观: Lyophilized or Liquid