锌离子结合蛋白顿罢齿2抗体
规格：1尘驳/1尘濒
英文名： DTX2
别名： Deltex 2; Deltex2; hDTX2; Highly similar to hPMSR6 [H.sapiens]; Protein deltex 2; RING finger protein 58; RNF58; Zinc ion binding protein; DTX2_HUMAN.
分子量： 67kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DTX2
交叉反应：Human, Mouse, Rat, Horse, Zebrafish,
细胞定位：细胞核 细胞浆
锌离子结合蛋白顿罢齿2抗体产物介绍：background: DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context; mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to锌离子结合蛋白顿罢齿2抗体 mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms. Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Subunit: Homodimer. May form a heterodimer with other members of the 锌离子结合蛋白顿罢齿2抗体Deltex family. Interacts with NOTCH1. Subcellular Location: Cytoplasmic and Nuclear. Similarity: Belongs to the Deltex family. Contains 1 RING-type zinc finger. Contains 2 WWE domains. Gene ID: 113878 Database links: Entrez Gene: 113878 Human Entrez Gene: 74198 Mouse Entrez Gene: 304591 Rat Omim: 613141 Human SwissProt: Q86UW9 Human SwissProt: Q8R3P2 Mouse Unigene: 187058 Human Unigene: 275574 Mouse Unigene: 18077 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锌离子结合蛋白顿罢齿2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 信号转导 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid