透明质酸酶/玻璃酸酶抗体
规格：1尘驳/1尘濒
英文名： Hyaluronidase-1
别名： HYA1; HYAL PH-20; HYAL PH20; HYAL1; HYAL3; HYAL5; Haase; Hyaluronidase PH-20; MGC26532; PH-20 Hyaluronidase; PH20; Hyaluronidase PH20; PH20 Hyaluronidase; SPAG15; SPAM-1; SPAM1;Sperm adhesion molecule
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from rat Haase
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 分泌型蛋白
透明质酸酶/玻璃酸酶抗体产物介绍：background: Hyaluronidase degrades hyaluronic acid, which is an important structural proteoglycan found in basement membranes and also extracellular matrices. There are six members of the hyaluronidase family. Hyaluronidase PH20 is a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane and plays a role in sperm penetration through the the hyaluronic acid-rich cumulus cell layer surrounding the oocyte. Abnormal expression of this gene has been implicated in degradation 透明质酸酶/玻璃酸酶抗体of basement membranes leading to tumor invasion and metastasis. Function: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Subcellular Location: Secreted. Lysosome. Tissue Specificity: Highly expressed in liver, kidney, lung and skin. Similarity: Belongs to the glycosyl hydrolase 56 family. Contains 1 EGF-like domain. Gene ID: 367166 Database links: Entrez Gene:透明质酸酶/玻璃酸酶抗体 3373 Human Entrez Gene: 15586 Mouse Entrez Gene: 404698 Pig Entrez Gene: 367166 Rat Omim: 607071 Human SwissProt: Q12794 Human SwissProt: Q91ZJ9 Mouse SwissProt: Q6RHW4 Pig SwissProt: Q76HN1 Rat Unigene: 75619 Human Unigene: 10305 Mouse Unigene: 475658 Mouse Unigene: 124438 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. HAase是一种具有高度底物特异性的蛋白酶，使透明质酸产生低分子化作用的酶之总称,可以特异地作用于透明质酸，通过裂解葡萄糖胺和葡萄糖醛酸的分子键而将透明质酸分解为二糖成分，引起透明质酸的解聚和降解，透明质酸分子从胶原细纤维间隙中释放出来并重新分布，主要定位于细胞外基质影响细胞的增殖、分化及迁移,并在胚胎发育和肿瘤发**展过程中发挥作用,因而它在胚胎发育、血管形成、**监视以及肿瘤发**展过程中起着重要作用。
透明质酸酶/玻璃酸酶抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid