软骨蛋白1抗体
规格：1尘驳/1尘濒
英文名： Alx1
别名： ALX homeobox 1; ALX homeobox protein 1; ALX1; ALX1_HUMAN; CART 1; CART-1; CART1; Cartilage homeoprotein 1.
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CART1/Al
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核
软骨蛋白1抗体产物介绍：background: The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. [provided by RefSeq, Jul 2008]. Function: Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development. Subunit: Interacts (via homeobox domain) with EP300. Subcellular Location: Nucleus. Tissue Specificity: Cartilage and cervix tissue. Post-translational modifications: Acetylated at Lys-131 by EP300,软骨蛋白1抗体 leading to increased interaction with EP300 and enhances transcriptional activation activity. DISEASE: Defects in ALX1 are the cause of frontonasal dysplasia type 3 (FND3) [MIM:613456]. The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation 软骨蛋白1抗体of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline. Similarity: Belongs to the paired homeobox family. Contains 1 homeobox DNA-binding domain. Gene ID: 8092 Database links: Entrez Gene: 8092 Human Omim: 601527 Human SwissProt: Q15699 Human Unigene: 41683 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
软骨蛋白1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 干细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid