同源结构蛋白1抗体
规格：1尘驳/1尘濒
英文名： MIXL1
别名： hMix; Homeobox protein MIXL1; Homeodomain protein 1; Homeodomain protein MIX; MILD1; MIX; Mix.1; Mix.1 homeobox-like protein; Mix1 homeobox-like 1; MIX1 homeobox-like protein 1; Mixl1; MIXL1_HUMAN.
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Human MIXL1
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
同源结构蛋白1抗体产物介绍：background: The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and in the control of gene expression. MIXL1 (Mix1 homeobox-like 1), also known as MIXL, is a 232 amino acid protein that localizes to the nucleus and contains one homeobox DNA-binding domain. Expressed in lymph tissues, MIXL1 functions as a transcription factor that plays an essential role in axial mesendoderm morphogenesis and endoderm formation and is also required for cellular differentiation during blood development. Additionally, MIXL1 is involved in maturation of heart and gut tissue during embryogenesis and may also act as a negative regulator of brachyury expression. Overexpression 同源结构蛋白1抗体of MIXL1 is associated with non-Hodgkin and Hodgkin lymphomas, suggesting a role in carcinogenesis. Function: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator 同源结构蛋白1抗体of brachyury expression. Subcellular Location: Nucleus. Tissue Specificity: Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is restricted to immature B-and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein level). Post-translational modifications: Phosphorylated at multiple sites. Similarity: Belongs to the paired homeobox family. Contains 1 homeobox DNA-binding domain. Database links: UniProtKB/Swiss-Prot: Q9H2W2.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
同源结构蛋白1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 信号转导 干细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid