早期发育调控蛋白1/贰顿搁1抗体
规格：1尘驳/1尘濒
英文名： PHC1
别名： Early development regulatory protein 1; EDR1 PH1; hPH1; mPH1; PH1; EDR1; Polyhomeotic-like protein 1; Rae28; PHC1_HUMAN.
分子量： 105kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Human EDR1/PHC
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞核
早期发育调控蛋白1/贰顿搁1抗体产物介绍：background: PHC1 is a 1,004 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Existing as a homodimer, PHC1 contains one FCS-type zinc finger and a SAM (sterile alpha motif) domain. PHC1 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Function: PHC1 is 早期发育调控蛋白1/贰顿搁1抗体a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The Polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators, such as Hox genes, and thus are essential for proper development. PHC1 is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. PHC1, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. 早期发育调控蛋白1/贰顿搁1抗体These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. Subcellular Location: Nuclear. Similarity: Contains 1 FCS-type zinc finger. Contains 1 SAM (sterile alpha motif) domain. Database links: Entrez Gene: 1911 Human Omim: 602978 Human SwissProt: P78364 Human Unigene: 305985 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
早期发育调控蛋白1/贰顿搁1抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 干细胞 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid