拮抗凋亡转录因子抗体
规格：1尘驳/1尘濒
英文名： AATF
别名： Apoptosis antagonizing transcription factor; CHE1; DED; AATF; AATF_HUMAN; Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1; Protein AATF;Rb binding protein Che 1.
分子量： 63kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AATF
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞核
拮抗凋亡转录因子抗体产物介绍：background: The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. Function: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell拮抗凋亡转录因子抗体 cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Subunit: Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT. Subcellular Location: Nucleus, nucleolus. Tissue Specificity: 拮抗凋亡转录因子抗体Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus. Post-translational modifications: Hyperphosphorylated during the G1/S phase transition. Similarity: Belongs to the AATF family. Gene ID: 26574 Database links: Entrez Gene: 26574 Human Entrez Gene: 56321 Mouse Omim: 608463 Human SwissProt: Q9NY61 Human SwissProt: Q3URN5 Mouse SwissProt: Q9JKX4 Mouse Unigene: 195740 Human Unigene: 257482 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. AATF属于细胞凋亡的拮抗转录因子,有抑制细胞凋亡的发展过程。
拮抗凋亡转录因子抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 细胞凋亡 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid