础罢笔结合蛋白家族6抗体
规格：1尘驳/1尘濒
英文名： ABCB6
别名： ABC; ABC14; EST45597; ABC 14; ABC-14; ABCB 6; ABCB-6; PRP; UMAT; ABC transporter umat; MTABC3; Mt-ABC transporter 3; umat; Mitochondrial precursor; Mitochondrial ABC transporter 3; Mitochondrial abc p
分子量： 94kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ABCB6
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig,
细胞定位：细胞膜 线粒体
产物介绍：background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) t础罢笔结合蛋白家族6抗体ransporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. Function: Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme 础罢笔结合蛋白家族6抗体synthesis Subunit: Homodimer. Subcellular Location: Cell membrane. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Tissue Specificity: Widely expressed. High expression is detected in the retinal epithelium. DISEASE: Microphthalmia, isolated, with coloboma, 7 (MCOPCB7) [MIM:614497]: A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic 础罢笔结合蛋白家族6抗体cup and stalk, and the fusion of the fetal fissure (optic fissure). Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain. Gene ID: 10058 Database links: Entrez Gene: 10058 Human Entrez Gene: 74104 Mouse Entrez Gene: 140669 Rat Omim: 605452 Human SwissProt: Q9NP58 Human SwissProt: Q9DC29 Mouse SwissProt: O70595 Rat SwissProt: Q9Z1S2 Rat Unigene: 107911 Human Unigene: 28663 Mouse Unigene: 54408 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ABCB6蛋白对于红细胞携带氧，肝细胞破坏**以及细胞从摄取营养物质后排放能量方面发挥重要的作用。
础罢笔结合蛋白家族6抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 信号转导 新陈代谢 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid