胚胎发育相关蛋白狈辞诲补濒抗体
规格：1尘驳/1尘濒
英文名： Nodal
别名： MGC138230; Nodal; nodal homolog (mouse); Nodal homolog; NODAL_HUMAN.
分子量： 13kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Human Nodal
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：分泌型蛋白
胚胎发育相关蛋白狈辞诲补濒抗体产物介绍：background: The transforming growth factor Beta (TGF Beta) superfamily is composed of numerous growth and differentiation factors, including TGF Beta 1-3, Mullerian inhibiting substance (MIS), growth/differentiation factor (GDF) 1-9, bone morphogenic protein (BMP) 2-8, glial cell line-derived neurotrophic factor (GDNF), Inhibin Alpha, Beta-A, Beta-B and Beta-C, Lefty and Nodal. Members of the TGF Beta superfamily are involved in embryonic development and tissue homeostasis. Ectodermal cells through the primitive streak delaminate and differentiate into mesoderm during gastrulation. Nodal expression is detectable in the primitive streak at the time胚胎发育相关蛋白狈辞诲补濒抗体 of mesoderm formation, indicating a potential role for Nodal in mesoderm formation. Nodal has also been shown to be involved in the direction of heart looping and embryonic turning. Function: Essential for mesoderm formation and axial patterning during embryonic development. Subunit: Homodimer; disulfide-linked (By similarity). Subcellular Location: Secreted. DISEASE: Defects in NODAL are the cause 胚胎发育相关蛋白狈辞诲补濒抗体of visceral heterotaxy autosomal type 5 (HTX5) [MIM:270100]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy autosomal type 5 include situs inversus viscerum or situs ambiguus, congenital heart defect, transposition of the great vessels ventricular septal defect, atrial septal defect, truncuscommunis, and dextrocardia. Similarity: Belongs to the TGF-beta family. Database links: UniProtKB/Swiss-Prot: Q96S42.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胚胎发育相关蛋白狈辞诲补濒抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 神经生物学 干细胞 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid