葡萄糖调节蛋白78抗体
规格：1尘驳/1尘濒
英文名： GRP78
别名： BIP; HSPA5; glucose regulated protein 78; 78 kDa glucose regulated protein; BIP; Endoplasmic reticulum lumenal Ca2+ binding protein grp78; FLJ26106; Glucose Regulated Protein 78kDa; GRP 78; GRP78; Hea
分子量： 78kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GRP78
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
葡萄糖调节蛋白78抗体产物介绍：background: The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide葡萄糖调节蛋白78抗体 isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Subcellular Location: Endoplasmic reticulum lumen. Melanosome. Identified by mass 葡萄糖调节蛋白78抗体spectrometry in melanosome fractions from stage I to stage IV. DISEASE: Note=Autoantigen in rheumatoid arthritis. Similarity: Belongs to the heat shock protein 70 family. Gene ID: 3309 Database links: Entrez Gene: 3309 Human Entrez Gene: 14828 Mouse Entrez Gene: 25617 Rat Omim: 138120 Human SwissProt: P11021 Human SwissProt: P20029 Mouse SwissProt: P06761 Rat Unigene: 605502 Human Unigene: 743241 Human Unigene: 330160 Mouse Unigene: 470180 Mouse Unigene: 11088 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 葡萄糖调节蛋白78是热休克蛋白70家族的成员之一又称：热休克蛋白70蛋白5,作为一种分子伴侣在蛋白质的折叠和转运过程及内质网应激反应中发挥重要作用.它在多种肿瘤组织中呈高表达.
葡萄糖调节蛋白78抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid