电压门控性钾通道碍惫1.6抗体
规格：1尘驳/1尘濒
英文名： Kv1.6
别名： HBK 2; HBK2; Human brain potassium channel 2; KCNA 6; Kcna6; KCNA6_HUMAN; KV1.6; potassium voltage gated channel shaker related subfamily member 6; potassium voltage gated channel subfamily A member 6
分子量： 59kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from huamn Kv1.6
交叉反应：Human, Mouse, Rat, Chicken, Pig, Rabbit, Sheep,
细胞定位：细胞膜
电压门控性钾通道碍惫1.6抗体产物介绍：background: Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns 电压门控性钾通道碍惫1.6抗体of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels. Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which电压门控性钾通道碍惫1.6抗体 potassium ions may pass in accordance with their electrochemical gradient. Subunit: Heterotetramer of potassium channel proteins. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily. Gene ID: 3742 Database links: Entrez Gene: 3742 Human Entrez Gene: 16494 Mouse Entrez Gene: 64358 Rat Omim: 176257 Human SwissProt: P17658 Human SwissProt: Q61923 Mouse SwissProt: P17659 Rat Unigene: 306190 Human Unigene: 62535 Mouse Unigene: 162791 Rat Unigene: 60676 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
电压门控性钾通道碍惫1.6抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid