细胞内流钾通道蛋白碍颈谤5.1抗体
规格：1尘驳/1尘濒
英文名： KIR5.1
别名： 6430410F18Rik; AI132396; BIR9; Inward rectifier K channel Kir5.1; Inward rectifier K(+) channel Kir5.1; Inward rectifier potassium channel 16; IRK16; IRKG; KCNJ16; MGC33717; Potassium channel inwardly
分子量： 48kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KIR5.1
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：细胞膜
细胞内流钾通道蛋白碍颈谤5.1抗体产物介绍：background: The KIR family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. Kir4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. Kir4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human Kir4.1 maps to chromosome 1. Kir4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human Kir4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and Kir4.2 may play a role 细胞内流钾通道蛋白碍颈谤5.1抗体in the pathogenesis of Down’s syndrome. Kir 5.1 forms functional channels only by coexpression with either Kir4.1 or Kir4.2 in the kidney and pancreas. The gene encoding human Kir5.1 maps to chromosome 17. Function: KIR5.1 is one of 20 members of the inwardly rectifying potassium (Kir) channel family. Due to its expression in kidney, pancreas and thyroid gland, it has been suggested that human KIR5.1 may be involved in the regulation of fluid and pH balance, thus making it a potential therapeutic target for hypertension, renal failure, or pancreatic 细胞内流钾通道蛋白碍颈谤5.1抗体disease. Subunit: Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2. Subcellular Location: Membrane; Multi pass membrane protein. Tissue Specificity: Highly expressed in kidney, pancreas and thyroid gland. Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily. Gene ID: 3773 Database links: Entrez Gene: 3773 Human Entrez Gene: 16517 Mouse Entrez Gene: 29719 Rat Omim: 605722 Human SwissProt: Q9NPI9 Human SwissProt: Q9Z307 Mouse SwissProt: P52191 Rat Unigene: 463985 Human Unigene: 1989 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞内流钾通道蛋白碍颈谤5.1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 通道蛋白 细胞膜受体 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid