磷酸化细胞内流钾通道蛋白碍颁狈闯1抗体
规格：1尘驳/1尘濒
英文名： phospho-KCNJ1(Ser44)
别名： KCNJ1 (phospho S44/25); KCNJ1 (phospho S44); p-KCNJ1 (phospho S44); KCNJ1 (phospho Ser44); p-KCNJ1 (Ser44); p-ROM-K(phospho S44); KCNJ1 (phospho S25); p-KCNJ1 (phospho S25); KCNJ1 (phospho Ser25); p-K
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Dog, Horse, Sheep,
细胞定位：细胞膜
磷酸化细胞内流钾通道蛋白碍颁狈闯1抗体产物介绍：background: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by磷酸化细胞内流钾通道蛋白碍颁狈闯1抗体 internal ATP and can be blocked by external barium. Subunit: Interacts with SGK1 and SLC9A3R2/NHERF2. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. Post-translational modifications: Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. DISEASE: Defects in KCNJ1 are the cause of Bartter syndrome type 2 (BS2) [MIM:241200]; also termed hyperprostanglandin E syndrome 2. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced 磷酸化细胞内流钾通道蛋白碍颁狈闯1抗体salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS2 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia. Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily. Gene ID: 3758 Database links: Entrez Gene: 3758 Human Entrez Gene: 56379 Mouse Entrez Gene: 24521 Rat Omim: 600359 Human SwissProt: P48048 Human SwissProt: O88335 Mouse SwissProt: P35560 Rat Unigene: 527830 Human Unigene: 390168 Mouse Unigene: 22609 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化细胞内流钾通道蛋白碍颁狈闯1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid