脑钠通道蛋白2抗体
规格：1尘驳/1尘濒
英文名： ACCN2
别名： ASIC1; ACCN2; ACCN2_HUMAN; Acid sensing ion channel 1; Acid sensing ion channel 1a protein; Acid sensing ion channel; Acid-sensing ion channel 1; AI843610; Amiloride sensitive cation channel 2 neurona
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ACCN2/AS
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
脑钠通道蛋白2抗体产物介绍：background: Acid sensing ion channel ASIC1 is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in t脑钠通道蛋白2抗体he inner ear. Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. Subunit: Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and 脑钠通道蛋白2抗体ASIC2 (By similarity). Interacts with PRKCABP. Subcellular Location: Cell membrane. Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4. Tissue Specificity: Expressed in most or all neurons. Post-translational modifications: Phosphorylation by PKA regulates interaction with PRKCABP and subcellular location. Phosphorylation by PKC may regulate the channel. Similarity: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN2 subfamily. Gene ID: 41 Database links: Entrez Gene: 538244 Cow Entrez Gene: 100720903 Guinea pig Entrez Gene: 100630368 Horse Entrez Gene: 41 Human Entrez Gene: 11419 Mouse Entrez Gene: 100517467 Pig Entrez Gene: 100355858 Rabbit Entrez Gene: 79123 Rat Entrez Gene: 407670 Zebrafish Entrez Gene: 407672 Zebrafish Entrez Gene: 791696 Zebrafish Omim: 602866 Human SwissProt: P78348 Human SwissProt: Q6NXK8 Mouse SwissProt: P55926 Rat SwissProt: Q708S6 Zebrafish SwissProt: Q708S7 Zebrafish SwissProt: Q708S8 Zebrafish Unigene: 274361 Human Unigene: 440107 Mouse Unigene: 37385 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脑钠通道蛋白2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid