突触融合蛋白结合蛋白5抗体
规格：1尘驳/1尘濒
英文名： Tomosyn/STXBP5
别名： FLJ30922; Lethal(2) giant larvae protein homolog 3; LGL3; LLGL3; MGC141942; MGC141968; Nbla04300; STXBP5; Syntaxin binding protein 5; Syntaxin-binding protein 5; Tomosyn 1; STXB5_HUMAN.
分子量： 127kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Tomosyn/
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
突触融合蛋白结合蛋白5抗体产物介绍：background: WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. Tomosyn, also known as STXBP5 (syntaxin binding protein 5), LLGL3 or LGL3, is a 1,151 amino acid protein that localizes to the cytoplasm, as well as to the cell junction, secretory vesicles and to the peripheral membrane and contains one v-SNARE coiled-coil homology domain and 14 WD repeats. Interacting with Syntaxin 1 and Syntaxin 1B, Tomosyn functions as a regulator of neurotransmitter release and calcium-dependent exocytosis. Additionally, Tomosyn inhibits membrane fusion and may play a role突触融合蛋白结合蛋白5抗体 in the assembly of SNARE complexes between transport vesicles and the plasma membrane. Multiple isoforms of Tomosyn exist due to alternative splicing events. Function: Tomosyn plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release by inhibiting the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane, via the displacement of munc18 from syntaxin-1. There are three splice variants of tomosyn designated m-tomosyn, b-tomosyn and s-tomosyn. Although b-tomosyn is ubiquitously expressed, s-tomosyn and m-tomosyn are expressed primarily in brain. Subunit: Interacts with STX1A and STX1B via its v-SNARE homology domain. Part of a complex that contains STX1, STXBP5, SNAP25 and SYT1. Part of a complex that contains STXBP5, STX4A and SNAP23. Subcellular Location: Cytoplasm. 突触融合蛋白结合蛋白5抗体Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles. Similarity: Belongs to the WD repeat L(2)GL family. Contains 1 v-SNARE coiled-coil homology domain. Contains 14 WD repeats. Gene ID: 134957 Database links: Entrez Gene: 134957 Human Entrez Gene: 78808 Mouse Entrez Gene: 81022 Rat Omim: 604586 Human SwissProt: Q5T5C0 Human SwissProt: Q8K400 Mouse SwissProt: Q9WU70 Rat Unigene: 93534 Human Unigene: 331751 Mouse Unigene: 96029 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
突触融合蛋白结合蛋白5抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞凋亡 细胞周期蛋白 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid