神经元电压门控钠通道蛋白β2/Na+ CP type IIβ抗体
规格：1尘驳/1尘濒
英文名： SCN2B
别名： Neuronal voltage gated sodium channel beta 2 subunit; Scn 2b; Scn2b; SCN2B_HUMAN; Sodium channel beta 2 subunit; Sodium channel subunit beta 2; Sodium channel subunit beta-2; Sodium channel voltage ga
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SCN2B
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞膜
神经元电压门控钠通道蛋白β2/Na+ CP type IIβ抗体产物介绍：background: Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarizes the cell. Na+ CP type II beta(sodium channel, voltage-gated, type II, beta), also known as SCN2B, is a 215 amino acid single-pass type I membrane protein that plays a critical role in the expression and assembly of the heterotrimeric complex of the sodium channel and interacts with Tenascin-R to influence the clustering and regulation of sodium channels at nodes of Ranvier. Expressed specifically in brain, Na+ CP type II beta contains one Ig-like C2-type (immunoglobulin-like) domain and is encoded by a gene that maps to human chromosome 神经元电压门控钠通道蛋白β2/Na+ CP type IIβ抗体11q23.3 and mouse chromosome 9 A5.2. Function: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. Subunit: [SUBUNIT] The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Brain specific. Similarity: Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.神经元电压门控钠通道蛋白β2/Na+ CP type IIβ抗体 Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Gene ID: 6327 Database links: Entrez Gene: 6327 Human Entrez Gene: 72821 Mouse Entrez Gene: 25349 Rat Omim: 601327 Human SwissProt: O60939 Human SwissProt: Q56A07 Mouse SwissProt: P54900 Rat Unigene: 129783 Human Unigene: 229373 Mouse Unigene: 477575 Mouse Unigene: 88636 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经元电压门控钠通道蛋白β2/Na+ CP type IIβ抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid