嘌呤受体笔2齿7抗体
规格：1尘驳/1尘濒
英文名： P2RX7
别名： ATP receptor; P2X purinoceptor 7; P2X7; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel 7; P2RX7_HUMAN.
分子量： 69kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human P2RX7 (1
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
细胞定位：细胞膜
嘌呤受体笔2齿7抗体产物介绍：background: The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP. Function: The product P2RX7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages 嘌呤受体笔2齿7抗体through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Subunit: Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Phosphorylation results in its inactivation. ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel (By similarity). Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is嘌呤受体笔2齿7抗体 required for efficient localization to cell surface. Similarity: Belongs to the P2X receptor family. Gene ID: 5027 Database links: Entrez Gene: 5027 Human Entrez Gene: 18439 Mouse Entrez Gene: 29665 Rat Omim: 602566 Human SwissProt: Q99572 Human SwissProt: Q9Z1M0 Mouse SwissProt: Q64663 Rat Unigene: 729169 Human Unigene: 42026 Mouse Unigene: 10510 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
嘌呤受体笔2齿7抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid