紧密连接蛋白惭鲍笔笔1抗体
规格：1尘驳/1尘濒
英文名： MUPP1
别名： MPDZ; Multi PDZ domain protein 1; Multi-PDZ domain protein 1; multiple PDZ domain protein; MPDZ_HUMAN.
分子量： 221kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MUPP1/MP
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
紧密连接蛋白惭鲍笔笔1抗体产物介绍：background: MPDZ is a 2,042 amino acid peripheral membrane protein that colocalizes with SR-2C on the apical membrane of epithelial choroid plexus cells. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas, MPDZ causes clustering of SR-2C, a serotonin receptor, at the cell surface. MPDZ is member of the NMDAR signaling complex that is involved in regulating AMPAR potentiation and synaptic plasticity in excitatory synapses. As a tight junction protein in epithelial cells, MPDZ interacts with SSTR3, a G-protein-coupled receptor, to regulate transepithelial permeability in a pertussis toxin sensitive manner. MPDZ, along with Kir4.2, may form a complex with other proteins in the nephron and regulate ion transport. MPDZ contains one L27 domain and thirteen PDZ domains. Function: MUPP1 was first identified as a protein interacting with type 2C serotonin receptor. It acts as a scaffolding protein at tight junctions where it has been reported to interact with integral proteins, anchoring them to the F-actin cytoskeleten. It is also thought to be important in the osmotic stress response in kidney cells and has 紧密连接蛋白惭鲍笔笔1抗体been shown to play a role in promoting G protein coupling to receptors. Subunit: Interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4 and MPP5 (By similarity). Interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A and CAMK2B. Interacts with the adenovirus type 9 E4-ORF1 protein. Subcellular Location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome. Note=Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on 紧密连接蛋白惭鲍笔笔1抗体dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. Tissue Specificity: Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Similarity: Contains 1 L27 domain. Contains 13 PDZ (DHR) domains. Gene ID: 8777 Database links: Entrez Gene: 8777 Human Entrez Gene: 17475 Mouse Entrez Gene: 29365 Rat SwissProt: O75970 Human SwissProt: Q8VBX6 Mouse SwissProt: O55164 Rat Omim: 603785 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
紧密连接蛋白惭鲍笔笔1抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 通道蛋白 细胞膜受体 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid